https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32651 30 kg/m²). Exacerbations requiring medical intervention were recorded prospectively. Asthma control, medication use, and fractional exhaled nitric oxide were assessed monthly; additional visits occurred during exacerbations. Peripheral blood was collected at baseline for the measurement of eosinophils, soluble CD-163, C-reactive protein, and IL-6. Results: Exacerbations occurred in a higher proportion of overweight (51.1%) and obese (48.4%) women compared with healthy weight women (25%; P =.026). Excess weight gain during pregnancy was not associated with exacerbation risk. Macrophage activation (elevated serum soluble CD-163) was associated with exacerbations requiring oral corticosteroids (P =.043), whereas high peripheral blood eosinophils or fractional exhaled nitric oxide were not associated with exacerbation or oral corticosteroid use. Conclusions: Being overweight or obese confers a greater risk of asthma exacerbation during pregnancy, and may be due to systemic macrophage activation.]]> Wed 19 Jan 2022 15:19:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34787 Wed 19 Jan 2022 15:18:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36096 Helicobacter pylori pathologies, cancer, coeliac disease, and autoimmune gastritis. Recent research is unraveling pathophysiology beyond symptom-only definitions, focusing on the duodenum with innate immune disturbance (duodenal eosinophilia) and microbial disruption as possible cause. Management of functional dyspepsia includes making a secure diagnosis, treatment with first-line proton pump inhibitors (PPI), then tricyclic antidepressants, and careful choice of prokinetics. Herbal treatments (peppermint oil) and STW-5 have in this age group limited efficacy. Summary: Further studies are needed to define the prevalence of functional dyspepsia in the elderly and of prime importance, to exclude organic disease as a cause for symptoms of dyspepsia.]]> Wed 15 Dec 2021 16:10:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41179 Wed 12 Jul 2023 11:51:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15695 Wed 11 Apr 2018 12:28:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15991 Wed 11 Apr 2018 11:51:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18363 Wed 11 Apr 2018 10:06:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34729 Wed 09 Mar 2022 15:59:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52880 Tue 31 Oct 2023 10:44:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49105 Tue 14 Nov 2023 14:40:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54156 Tue 06 Feb 2024 12:11:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36051 Thu 28 Oct 2021 13:04:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26123 Thu 28 Oct 2021 13:04:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49306 Thu 11 May 2023 14:32:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36097 Helicobacter pylori and other pathophysiological changes, most notably duodenal pathology, namely duodenal eosinophilia, permeability alterations, structural neuronal changes and microbial duodenal dysbiosis. This has led to the idea that FD is a true disease entity and triggers of this condition based on epidemiology studies point towards allergy, immune disorders and infection. Anxiety and depression may precede or follow FD, (brain-gut/gut-brain disorders). Currently most therapies for FD are inadequate but underlying pathology may lead to targeted treatment success as an attainable goal.]]> Thu 06 Feb 2020 09:59:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9455 Sat 24 Mar 2018 08:41:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7531 Sat 24 Mar 2018 08:38:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7255 Sat 24 Mar 2018 08:33:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7690 Sat 24 Mar 2018 08:33:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12382 Sat 24 Mar 2018 08:18:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13322 Sat 24 Mar 2018 08:16:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17923 Sat 24 Mar 2018 07:56:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19229 9/L. The blood eosinophil/lymphocyte ratio (ELR) and eosinophil/neutrophil ratio (ENR) were increased in eosinophilic asthma, and the neutrophil/lymphocyte ratio (NLR) was increased in neutrophilic asthma. Neutrophilic asthma could also be detected by blood neutrophil percentages and NLR, but with less accuracy. Conclusions and Clinical Relevance: Blood eosinophil counts and derived ratios (ELR and ENR) can accurately predict eosinophilic asthma in patients with persistent uncontrolled asthma despite treatment. Blood neutrophil parameters are poor surrogates for the proportion of sputum neutrophils. Blood counts may be a useful aid in the monitoring of uncontrolled asthma.]]> Sat 24 Mar 2018 07:54:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20655 Sat 24 Mar 2018 07:49:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5180 Sat 24 Mar 2018 07:47:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29214 Sat 24 Mar 2018 07:36:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30557 Sat 24 Mar 2018 07:27:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55058 Mon 08 Apr 2024 09:43:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51709 Fri 15 Sep 2023 14:09:51 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38377 Fri 10 Sep 2021 12:38:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37118 Fri 03 Dec 2021 10:32:20 AEDT ]]>